Pluripotent Stem Cell–Based Approaches in Alzheimer’s Disease: Evidence from Disease Modelling, Therapeutic Screening, and Ethical Perspectives

Author(s)	Ms. Aarsheya Prashant Vasavada
Country	India
Abstract	Alzheimer’s disease (AD), which contributes around 60-80% of cases, currently represents the most prevalent form of dementia. However, with predictions of such drastic increases in the global incidence of dementia, development of more informative models of Alzheimer’s disease remains a prerequisite. Among various recent advances, one of the most promising support tools, along with more widely regarded technologies such as ESCs, has been given by iPSCs, which could represent one of the most acceptable alternatives to ESCs. From today’s perspective, iPSC-derived models of Alzheimer’s disease could undoubtedly revolutionize our current views of AD’s early pathology. However, one of the most crucial facts associated with iPSC-based models of AD has been recognized as the difficulty of reproducing both senescence in AD as well as late AD.
Keywords	Induced pluripotent stem cells (iPSCs); Alzheimer’s disease; disease modelling; brain organoids; neural differentiation; amyloid-beta pathology; tau pathology; drug screening; personalized medicine; ethical considerations
Field	Sociology > Philosophy / Psychology / Religion
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-03-03

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