International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Comprehensive Assessment on the Neuroprotective Effect of Moringa Oleifera Leaf Extracts to Prevent Alzheimer's Disease: A Review

Author(s) Dr. Gulshan Kumar, Sanjay Kumar Srivastava, Anjana devi
Country India
Abstract ABSTRACT
Alzheimer’s disease (AD) is a progressive neurodegenerative disorder characterized by oxidative stress, neuroinflammation, cholinergic dysfunction, and abnormal protein aggregation. The present study investigated the neuroprotective potential of the hydroethanolic leaf extract of Moringa oleifera in an experimental model of AD. Phytochemical analysis revealed a high content of bioactive constituents, with total phenolic and flavonoid contents of 87.4 ± 2.3 mg GAE/g and 64.8 ± 1.9 mg QE/g extract, respectively. The extract demonstrated significant in vitro antioxidant activity, including DPPH radical scavenging (IC₅₀ = 62.4 ± 1.8 µg/mL), ferric reducing antioxidant power, and metal chelating capacity, along with notable anti-inflammatory activity in the protein denaturation assay.
In vivo evaluation showed that extract treatment significantly improved spatial learning and memory in the Morris Water Maze, Y-maze, and Novel Object Recognition tests, comparable to the standard drug Donepezil. Biochemical investigations revealed a marked reduction in lipid peroxidation and acetylcholinesterase activity, alongside restoration of antioxidant enzymes (SOD, CAT, GPx). Furthermore, the extract significantly suppressed pro-inflammatory cytokines (TNF-α, IL-1β, IL-6). Neuropathological analysis demonstrated reduced amyloid-β deposition, decreased tau hyperphosphorylation, and preservation of hippocampal neuronal integrity.
Collectively, these findings indicate that Moringa oleifera exerts multi-target neuroprotective effects through antioxidant reinforcement, anti-inflammatory modulation, and cholinergic regulation. The study highlights its potential as a promising phototherapeutic candidate for the management or prevention of Alzheimer’s disease.
Keywords: Alzheimer’s disease; Moringa oleifera; Neuroprotection; Antioxidant activity; Neuroinflammation; Acetylcholinesterase inhibition; Amyloid-β; Tau hyperphosphorylation; Cognitive function.
Keywords Alzheimer’s disease; Moringa oleifera; Neuroprotection; Antioxidant activity; Neuroinflammation; Acetylcholinesterase inhibition; Amyloid-β; Tau hyperphosphorylation; Cognitive function.
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-07
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E-ISSN 2582-2160
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