Innovative Interventions to Enhance Cervical Cancer Screening Adherence: A Systematic Review and Meta-Analysis

Sankara Selvi Malaiyandi

doi:10.36948/ijfmr.2026.v08i02.71070

Innovative Interventions to Enhance Cervical Cancer Screening Adherence: A Systematic Review and Meta-Analysis

Author(s)	Prof. Sankara Selvi Malaiyandi
Country	India
Abstract	Background: Cervical cancer screening adherence remains suboptimal globally despite proven efficacy in reducing mortality. Innovative interventions are essential to bridge behavioral gaps and improve screening uptake. Objective: To systematically evaluate and meta-analyze the effectiveness of innovative interventions in enhancing cervical cancer screening adherence across diverse populations. Methods: Following PRISMA 2020 guidelines, we searched PubMed, Cochrane Library, Embase, and Web of Science (inception-December 2024) for randomized controlled trials (RCTs) and quasi-experimental studies evaluating adherence interventions. Two reviewers independently screened studies, extracted data, and assessed bias using the Cochrane Risk of Bias tool. Random-effects meta-analysis calculated pooled odds ratios (OR) with 95% confidence intervals (CI). Heterogeneity was quantified using I² statistics and explored through subgroup analyses and meta-regression. Results: Twenty-five studies (n=52,348 participants) were included. Innovative interventions significantly improved screening adherence (pooled OR: 1.87, 95% CI: 1.58-2.22, p<0.001; I²=62%). Subgroup analysis revealed: digital health interventions (OR: 2.24, 95% CI: 1.85-2.71; I²=48%), community-based programs (OR: 1.82, 95% CI: 1.46-2.27; I²=55%), patient navigation (OR: 1.68, 95% CI: 1.35-2.09; I²=41%), and self-sampling HPV testing (OR: 1.59, 95% CI: 1.24-2.04; I²=38%). Meta-regression identified intervention intensity (β=0.28, p=0.012) and baseline adherence rates (β=-0.35, p=0.008) as significant effect modifiers. Funnel plot asymmetry and Egger's test (p=0.042) suggested potential publication bias, attenuated after trim-and-fill analysis (adjusted OR: 1.76, 95% CI: 1.48-2.09). Conclusion: Innovative, theory-driven interventions substantially enhance cervical cancer screening adherence. Digital health strategies demonstrate superior effectiveness. Implementation should prioritize evidence-based, culturally tailored approaches with rigorous heterogeneity assessment to optimize population-level impact.
Keywords	Cervical cancer screening, adherence, meta-analysis, PRISMA, heterogeneity, digital health interventions, behavioral interventions
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-03-19
DOI	https://doi.org/10.36948/ijfmr.2026.v08i02.71070

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Innovative Interventions to Enhance Cervical Cancer Screening Adherence: A Systematic Review and Meta-Analysis

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