International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 8 Issue 2
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Medicinal Herbs in Metabolic Regulation: Mechanistic Insights into the Dual Management of Type 2 Diabetes and Dyslipidemia

Author(s) Ms. Simran Gupta, Dr. Karuna Singh
Country India
Abstract Type 2 diabetes mellitus (T2DM) and dyslipidemia commonly coexist and increase cardiovascular risk through interconnected mechanisms involving insulin resistance, oxidative stress, and chronic inflammation. While conventional pharmacological therapies effectively control metabolic abnormalities, concerns related to side effects, cost, and long-term adherence have encouraged exploration of medicinal herbs as complementary multi-target interventions. This review provides a mechanism-based overview of medicinal herbs with dual antidiabetic and antilipidemic potential, integrating evidence from both preclinical and clinical studies.

Medicinal herbs regulate metabolic homeostasis through multiple pathways, including enhancement of insulin secretion, improvement of insulin sensitivity via AMPK and PI3K/Akt signaling, inhibition of carbohydrate-digesting enzymes, modulation of lipid metabolism, and reduction of oxidative and inflammatory stress. Botanicals such as Trigonella foenum-graecum, Curcuma longa, Momordica charantia, Berberis aristata, and Allium sativum demonstrate overlapping mechanisms that simultaneously influence glucose and lipid regulation. Antioxidant phytochemicals further support β-cell protection and metabolic balance.

Despite promising mechanistic evidence, clinical translation remains limited due to variability in extract standardization, dosage, and study design, with several herbs still supported mainly by preclinical data. Future research should focus on standardized formulations and well-designed clinical trials to establish evidence-based therapeutic applications for metabolic disorders.
Keywords Type 2 diabetes mellitus, dyslipidemia, medicinal herbs, insulin resistance, oxidative stress
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-16
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.71611
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