International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Chemotherapy-Induced Cardiotoxicity in Breast and Haematological Cancers: A Comprehensive Review

Author(s) Dr. Sridevi Chokkakula, Ms. Tharuni Chinnaroyyala, Mr. Deemanth Reddy Gantla, Ms. Navya Vemula
Country India
Abstract In recent years, chemotherapeutic regimens have advanced with great success that has enhanced survival rates in patients with breast and haematological malignancies. Nevertheless, the rising life expectancy among cancer patients has made long-term adverse effects of the treatment more prominent, and cardiotoxicity is one of the leading causes of morbidity and mortality.
Cardiotoxicity caused by chemotherapy involves a continuum of structural and functional cardiac pressures that comprise of left ventricular dysfunction (asymptomatic), left ventricular dysfunction (symptomatic), heart failure (overt), arrhythmias, ischemic heart disease, and cardiomyopathy. The cardiotoxic risk is specifically linked with breast cancer and haematological malignancies, as anthracyclines, HER2-targeted therapy, alkylating therapy use, and the use of more recent targeted and immune-based therapy are common. This review is a comprehensive and clinically structured review on the mechanisms, risk factors, clinical manifestation, diagnostic interventions, and treatment of chemotherapy-induced cardiotoxicity in breast and haematological malignancies. The focus is made on early detection and preventive measures as well as the growing role of clinical pharmacists as a part of multidisciplinary cardio-oncology care. These points are important to understand how to maximize the oncologic outcomes with the minimal cardiovascular problems.
Keywords Chemotherapy-induced cardiotoxicity ,Breast cancer ,Haematological malignancies ,Anthracyclines, HER2-targeted therapy, Cardio-oncology, Left ventricular dysfunction.
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-29
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E-ISSN 2582-2160
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