Spectrum of Histopathological Findings in Hysterectomy Specimens for Abnormal Uterine Bleeding: A Clinicopathological Correlation Study at a Tertiary Care Center.

Ekta Jaiswal; Honey Bhasker Sharma; Tripti Singh; Nikhilesh kumar; Monika Gupta; Megha Bansal; Parul Verma; Navdeep Kaur

doi:10.36948/ijfmr.2026.v08i02.71746

Spectrum of Histopathological Findings in Hysterectomy Specimens for Abnormal Uterine Bleeding: A Clinicopathological Correlation Study at a Tertiary Care Center.

Author(s)	Dr. Ekta Jaiswal, Dr. Honey Bhasker Sharma, Dr. Tripti Singh, Dr. Nikhilesh kumar, Dr. Monika Gupta, Dr. Megha Bansal, Dr. Parul Verma, Dr. Navdeep Kaur
Country	India
Abstract	ABSTRACT Background Abnormal uterine bleeding (AUB) is a common gynaecological complaint in reproductive and perimenopausal women, often requiring hysterectomy when refractory to conservative management. Histopathological examination of hysterectomy specimens is essential to confirm diagnoses and detect incidental pathologies. Objectives This study evaluated the spectrum of diseases associated with AUB in hysterectomy specimens and their clinico-pathological correlation. Methods A cross-sectional study was conducted over 18 months at the Department of Pathology, T.S. Misra Medical College and Hospital, Lucknow. Eighty-seven hysterectomy specimens from women with AUB were included. Clinical details, ultrasonographic findings, and histopathological features (H&E, special stains, ER/PR immunohistochemistry where indicated) were recorded and analysed. Results Heavy menstrual bleeding was the commonest presentation (46.0%), followed by peri-menopausal bleeding (21.8%). Ultrasonography most frequently showed uterine fibroid (34.6%) and thickened endometrium (33.3%). Histopathologically, leiomyoma predominated (37.9%), followed by endometrial hyperplasia (17.2%), endometrial polyp (12.6%), and adenomyosis (11.5%). Cervical carcinoma (3.4%) and endometrial carcinoma (2.3%) were also identified. Multiple pathologies coexisted in 45.5% of leiomyoma cases. A significant association existed between clinical presentations and hysterectomy indications (p < 0.001). Conclusion Leiomyoma was the most frequent histopathological diagnosis in AUB-related hysterectomies, followed by endometrial hyperplasia, with peak incidence in perimenopausal women. Good clinicopathological correlation was observed, particularly for benign lesions. Routine histopathological examination is recommended to identify unsuspected malignancies and coexisting pathologies.
Keywords	Abnormal uterine bleeding, Hysterectomy, Leiomyoma, Clinico-pathological correlation Histopathology
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-03-16
DOI	https://doi.org/10.36948/ijfmr.2026.v08i02.71746

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Spectrum of Histopathological Findings in Hysterectomy Specimens for Abnormal Uterine Bleeding: A Clinicopathological Correlation Study at a Tertiary Care Center.

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