International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 2
March-April 2026

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Formulation And Evaluation Of Gastroretentive Floating Tablet Of Ciprofloxacin

Author(s) Ms. Madhavi Pidaparthi, Ms. Satyasri Katari, Mr. Ashok Kesana, Ms. Sandhyarani Aradhyula, Ms. Anjali Chekuri
Country India
Abstract Abstract:
the present investigation aimed to develop and evaluate a gastro retentive effervescent floating tablet of ciprofloxin hydrochloride to enhance gastric residence time and sustain drug release in the upper gastrointestinal tract.ciprofloxacin exhibits site-specific absorption in the stomach and proximal small intestine.therefore prolongation of gastric retention is expected to improve its bioavailability and therapeutic efficacy.an effervescent floating drug delivery system(FDDS) was formulated using sodium bicarbonate as a gas- generating agent and hydrophilic matrix-forming polymer to ensure buoyancy and controlled drug release. Tablets were prepared by direct compression method and evaluated for precompression parameters including angle of repose, bulk density, tapped density. Hausner’s ratio and carr’s index to assess flow properties. Post compression evaluation involved hardness,friability,weight variation,thickness,drug content uniformity, floating lag time,total floating time,swelling index and in vitro dissolution studies in 0.1N HCl .the study concludes that the developed gastro retentive effervescent floating tablet of ciprofloxacin provides prolonged gastric retention with controlled drug release fllowing diffusion -controlled drug release,thereby offering a promising approach for improving bioavailability and patient compliance in antibacterial therapy.
Keywords Keywords: ciprofloxacin, hydrochloride, gstro retentive drug delivery system, floating tablet,HPMC,effervescent system.
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-20
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E-ISSN 2582-2160
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