International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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An Overview Bioprocess Optimization and Scale-Up of Aspergillus niger for Amylase Production: Recent Advances in Fermentation Technology

Author(s) Mr. Ravi Sadashiv Khandare, Ms. Harshada Kiran Sonawane, Ms. Khushi Parewal, Dr. Vipul Patel, Dr. Pratim Kumar Choudhary
Country India
Abstract Amylases are among the most extensively used industrial enzymes, playing a crucial role in various biotechnological applications within the textile, detergent, pharmaceutical, food, and biofuel industries. Aspergillus niger stands out as a favoured industrial microorganism due to its exceptional ability to secrete enzymes extracellularly, its metabolic flexibility, its capacity to thrive on inexpensive substrates, and its regulatory approval for producing food-grade enzymes. Progress in the fermentation technology has significantly boosted amylase production by optimising physicochemical conditions, introducing innovative bioreactor designs, and utilizing computational modelling and statistical techniques. This review highlights a detailed and integrated evaluation of current bioprocess strategies aimed at enhancing α-amylase production from Aspergillus niger. It explores both submerged and solid-state fermentation methods, focusing on critical optimization factors such as pH, aeration, temperature, and nutrient composition, along with modern modelling tools like response surface methodology, central composite design, and artificial neural networks. It also significantly examines engineering challenges related to scaling-up, especially those concerning oxygen transfer limitations, reactor hydrodynamics, and process control in industrial and pilot systems. Along with this, it analyses downstream processing strategies, enzyme stabilization methods, and major industrial application pathways. Emerging trends, including the valorisation of agro-industrial residues, metabolic and genetic engineering of production hosts, and the integration of enzyme manufacturing within circular bioeconomy frameworks, that are synthesized to showcase the future technological directions. By consolidating recent literature across microbial physiology, fermentation engineering, and industrial biotechnology, this review provides a systems-level perspective on sustainable and economically viable amylase biomanufacturing and identifies key research opportunities for advancing large-scale enzyme production.
Keywords Aspergillus niger, α- Amylase Production, Fermentation Optimization, Bioprocess Scale-up, Submerged Fermentation, Solid-State Fermentation
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-03-25
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.72420
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