International Journal For Multidisciplinary Research

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Hypercalcemia as an Unusual Manifestation of Recurrent Graves’ Disease: A case report

Author(s) Dr. Meryem Eladla, Prof. Zineb Elazime, Prof. Mohammed Amine Essafi, Prof. Hayat Aynaou, Prof. Houda Salhi
Country Morocco
Abstract Malignancy and primary hyperparathyroidism are the most common causes of hypercalcemia, a common biochemical abnormality. In clinical practice, hyperthyroidism may be disregarded as a less frequent cause of parathyroid hormone (PTH)-independent hypercalcemia. We describe the case of a 58-year-old woman who had persistent moderate hypercalcemia and recurrent Graves' disease.

The patient had a history of Graves' disease, which was first treated with carbimazole and then thyroid lobectomy. Due to inadequate treatment compliance, the patient later experienced a relapse. Thyrotoxicosis was confirmed by laboratory testing, which showed elevated FT3 and FT4 levels and suppressed TSH. Excluding primary hyperparathyroidism, calcium levels with suppressed PTH ranged from 116 to 124 mg/L. Malignancy and other secondary causes of hypercalcemia were ruled out by thorough investigations.

After receiving intravenous hydration and antithyroid medication, the patient's calcium levels gradually returned to normal. Following definitive treatment with a total thyroidectomy, euthyroidism was restored and serum calcium levels fully returned to normal.

This case emphasizes the importance of taking hyperthyroidism into account when making a differential diagnosis for PTH-independent hypercalcemia. By controlling thyrotoxicosis, early detection of this association may avoid needless investigations and enable appropriate management.
Keywords Hypercalcemia-Graves’ Disease-hyperthyroidism-thyrotoxicosis
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-12
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.73141
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