International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 8 Issue 2
March-April 2026

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Combating Multidrug-Resistant Enterococcal Infections: Current Management Strategies and Emerging Therapeutic Approaches

Author(s) Dr. Khushbu Gautam
Country India
Abstract Abstract
Multidrug-resistant enterococci (MDR-E), particularly Enterococcus faecium and Enterococcus faecalis, have emerged as major nosocomial pathogens responsible for severe infections such as bloodstream infections, endocarditis, urinary tract infections, and intra-abdominal infections. The increasing prevalence of vancomycin-resistant enterococci (VRE) and the emergence of strains resistant to last-line agents such as linezolid and daptomycin have significantly limited therapeutic options. Enterococci exhibit remarkable genomic plasticity and can acquire resistance determinants via horizontal gene transfer, enabling rapid dissemination in hospital environments. Globally, the prevalence of VRE has increased dramatically over the past two decades, posing significant clinical and economic challenges. This review provides a comprehensive overview of the epidemiology, molecular mechanisms of resistance, clinical impact, and current management strategies for MDR enterococcal infections. In addition, emerging therapeutic approaches such as novel oxazolidinones, lipoglycopeptides, antimicrobial peptides, bacteriophage therapy, and combination antibiotic therapy are discussed. Effective management of MDR enterococcal infections requires a multidisciplinary approach that integrates antimicrobial stewardship, infection control measures, and ongoing research into innovative therapeutic strategies.
Keywords Keywords: Enterococcus, vancomycin-resistant enterococci, antimicrobial resistance, linezolid, daptomycin, multidrug resistance.
Field Biology > Bio + Chemistry
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-12
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E-ISSN 2582-2160
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