International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

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Volume 8 Issue 2
March-April 2026

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Gram-Positive Infections: From Clinical Burden to Innovative Treatment Strategies

Author(s) Dr. Khushbu Gautam
Country India
Abstract Abstract
Serious infections caused by Gram-positive bacteria remain a major public health challenge globally due to the increasing prevalence of antimicrobial resistance. Pathogens such as Staphylococcus aureus, Enterococcus spp., and Streptococcus pneumoniae are responsible for a wide range of life-threatening infections including pneumonia, meningitis, bacteremia, endocarditis, osteomyelitis, and device-associated infections. The emergence of multidrug-resistant strains such as methicillin-resistant Staphylococcus aureus (MRSA), vancomycin-resistant enterococci (VRE), vancomycin-intermediate S. aureus (VISA), and vancomycin-resistant S. aureus (VRSA) has significantly limited therapeutic options and increased healthcare costs and mortality. In addition, resistance to newer antimicrobial agents including linezolid and quinupristin-dalfopristin has also been reported. This review examines the epidemiology, resistance mechanisms, clinical impact, and treatment challenges associated with Gram-positive infections. Strategies for prevention and control including antimicrobial stewardship, infection prevention practices, vaccination, and development of novel antibiotics are discussed. Addressing the growing burden of Gram-positive infections requires integrated global efforts combining clinical management with innovative drug discovery.
Keywords Keywords: Gram-positive infections, MRSA, VRE, antimicrobial resistance, Staphylococcus aureus, antibiotic resistance
Field Biology > Bio + Chemistry
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-12
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E-ISSN 2582-2160
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