International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Review On Microneedle Transdermal Drug Delivery System

Author(s) Dr. Devendra L Visokar, Mr. Abhishek C Jampangire, Dr. Upendra C Galgatte, Ms. Pooja S Ghatole
Country India
Abstract Transdermal drug administration is very advantageous because it allows medications to be given through the skin without having first-pass metabolism, giving the patient an ongoing steady state of drug in their bloodstream, and therefore increases the safety and comfort of patients. However, there are some difficulties associated with transdermal drug delivery because the skin presents such a barrier to drug passage. The stratum corneum, or outermost layer of skin, acts as a significant barrier to drug entry. It only allows a small number of drugs to pass through it naturally. Microneedles are a new, simple, yet non-invasive solution to this issue. Microneedles create micro-channels (or micro-pathways) in the skin that allow the drug to be able to penetrate through the top layers of skin without providing a significant amount of pain. Multiple designs have been developed for microneedles, such as solid, coated, hollow, dissolving and hyaluronic gel-forming types. These designs utilise a variety of materials including metals, silicon or biocompatible polymers. The purpose of this review article is to provide an overview of the different microneedles’ key characteristics, methods of fabrication, primary assessment method(s), and growing usage in relation to the administration of pharmaceuticals, vaccines and/or diagnostics. Although there is great potential for further applications within the healthcare field, there are still many challenges that exist, including improvements to the mechanical integrity of needles; improvement of drug storage capabilities; prolonged release of target drug; reduction in production costs; and scaling-up for mass production
Keywords Skin ; Transdermal Route; Polymeric Needles; Drug Delivery; Microneedle
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-08
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.73454
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