International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 2
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Role of PRF and Interaction of Other Drugs in Implant Prostheses

Author(s) Dr. Ronika Nipana, Dr. Aanchal Kohli, Dr. Nilima Bukte, Sufiyan Ansari, Ashhad Ameen, Saquib Mehmood
Country India
Abstract Implant prosthodontics continues to develop rapidly with expanding treatment possibilities and improved biologic understanding of implant-supported rehabilitation. The long-term predictability of implant therapy depends largely on successful osseointegration, which is influenced by both local healing conditions and systemic pharmacological factors. Various drugs and biologic adjuncts can modify bone remodeling, angiogenesis, and tissue regeneration around implants. Platelet-rich fibrin (PRF) is an autologous platelet- and leukocyte-rich fibrin concentrate derived from blood that has shown regenerative potential because of its ability to release growth factors gradually during healing. In addition to PRF, several pharmacological agents such as antibiotics, anti-inflammatory drugs, bisphosphonates, statins, vitamin D, and bone-regulating molecules have been investigated for their influence on implant integration and peri-implant tissue response. PRF and its modifications, including advanced PRF and injectable PRF, together with platelet-rich plasma, have broadened regenerative applications in implant dentistry by improving wound healing, angiogenesis, and tissue maturation. This review discusses the biologic basis, preparation principles, clinical applications, advantages, limitations, and recent evidence regarding PRF and other pharmacological agents in implant prosthodontics, emphasizing their relevance as adjuncts in regenerative implant therapy and their role in evidence-based clinical practice.
Keywords Platelet-rich fibrin, dental implants, osseointegration, implant prosthodontics, pharmacological agents
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-09
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E-ISSN 2582-2160
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