Comparative Study of Disease Severity in Ulcerative Colitis vs. Crohn’s Disease in the Indian Population: A Multicenter Analysis

Author(s)	Dr. MOHAMMED KHAJA MOINUDEEN, Dr. ABDUL REHMAN, Dr. DANISH BAGDADI, Dr. ABDUL MUYEED, Dr. FARAJ KHAN
Country	India
Abstract	The global "second wave" of Inflammatory Bowel Disease (IBD) is currently peaking in newly industrialized nations. India, with a population exceeding 1.4 billion, is witnessing a transition from infectious to idiopathic chronic inflammatory disorders. While Western IBD is often linked to the NOD2 gene, Indian patients show a stronger correlation with HLA-DRB1*0103 and TNFSF15 polymorphisms. The "Hygiene Hypothesis" in India is unique; rapid urbanization and the shift from high-fiber traditional diets to "Westernized" ultra-processed foods (UPF) have altered the gut microbiome (dysbiosis), leading to an early-onset, aggressive disease phenotype. This study compares the clinical severity and progression of UC vs. CD in this specific demographic.
Keywords	Inflammatory Bowel Disease, Ulcerative Colitis, Crohn’s Disease, India, Intestinal Tuberculosis, Pancolitis, Phenotype.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-04-16

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research