International Journal For Multidisciplinary Research

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Role of Magnetic Resonance Imaging Diffusion Weighted And Apparent Diffusion Coefficient Evaluation In Brain Infarction

Author(s) Dr. Tanzeem Siddiqui, Dr. Lavan Saxena, Dr. Muktakar Singh, Dr. Robin Verma, Dr. Jayesh Bonde, Dr. Neeraj Singh, Dr. Jyothi Reddy
Country India
Abstract BACKGROUND- Cerebral infarction is a leading cause of mortality and long-term neurological disability worldwide. Early and accurate diagnosis is crucial for timely therapeutic intervention and improved clinical outcomes. Diffusion-Weighted Imaging (DWI) and Apparent Diffusion Coefficient (ADC) mapping on Magnetic Resonance Imaging (MRI) have emerged as highly sensitive tools for the early detection and characterization of ischemic brain lesions.

MATERIAL AND METHOD- This prospective observational study was conducted in the Department of Radio-Diagnosis at a tertiary care hospital. About 50 clinically suspected patients of ischemic stroke underwent MRI brain including DWI and ADC sequences at 1.5 Tesla Philips MRI machine. The distribution of infarcts, vascular territory involvement, and ADC values were analyzed and correlated with the clinical stage of infarction.

RESULT- DWI demonstrated high sensitivity in detecting acute cerebral infarcts, showing hyperintense signals within minutes of symptom onset. Corresponding ADC maps revealed reduced ADC values in acute infarction, with pseudo-normalization in subacute stages and increased values in chronic infarcts. Middle cerebral artery territory was the most commonly involved. ADC quantification aided in differentiating acute from subacute and chronic infarctions.

CONCLUSION- Diffusion-Weighted Imaging combined with ADC mapping is a reliable, non-invasive, and highly sensitive modality for early diagnosis and staging of cerebral infarction. It plays a pivotal role in guiding clinical decision-making and improving patient management. This study reinforce the essential role of diffusion imaging and ADC in modern neuroimaging and advocate its use in evaluation and early management of patients with suspected ischemic stroke.
Keywords Cerebral infarction, Diffusion-weighted imaging, Apparent diffusion coefficient, MRI, Stroke
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-09
DOI https://doi.org/10.36948/ijfmr.2026.v08i02.73917
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