International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 2
March-April 2026

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Evaluation of the efficacy of exfoliative oral brush cytology in malignancies of oral cavity and oropharynx

Author(s) Dr. Rakshita Devi Varun Segar, Dr. Sathiyabhama S
Country India
Abstract Aim and objectives: To evaluate the usefulness of exfoliative cytology in diagnosing malignant lesions of the oral cavity and oropharynx.
Materials and Methods: This prospective study was conducted in the Department of ENT at a tertiary care center from October 2024 to October 2025. A total of 30 patients with clinically suspected malignant oral or oropharyngeal lesions were included. Exfoliative cytology samples were obtained using a brush or spatula, stained (Papanicolaou/Romanowsky), and analyzed. Results were compared with histopathological findings.
Results: Among 30 patients, 22 were males and 8 females. The tongue was the most frequently affected site. Cytology detected premalignant or malignant changes in 20 cases, with 10 false negatives and no false positives. The sensitivity and specificity were 66.67% and 100%, respectively. Positive predictive value was 100%, negative predictive value was 50%, and overall diagnostic accuracy was 75%.
Conclusion: Exfoliative cytology is a simple, cost-effective, and minimally invasive screening tool for early detection of oral malignancies. Histopathological examination may remain the gold standard for diagnosing oral cavity biopsies but cytology can be used as an adjunct for screening and follow-up.
Keywords Oropharyngeal carcinoma, Exfoliative cytology, Screening
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-10
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E-ISSN 2582-2160
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