International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 2 (March-April 2026) Submit your research before last 3 days of April to publish your research paper in the issue of March-April.

Utilization pattern of dipeptidyl peptidase IV inhibitors in diabetes mellitus patients

Author(s) Ms. Shaik Khamar E Azam, Dr.V.Satyanarayana, B.Lalitha Bai, T.Venu, Sk.Mahaboob Subhani
Country India
Abstract Type 2 diabetes mellitus is a rapidly growing global health concern, with its prevalence projected to increase significantly in the coming years. The disease is linked to multiple long-term complications that affect various organ systems, contributing to increased morbidity, mortality, and healthcare burden worldwide. Due to its multifactorial nature, management strategies for type 2 diabetes involve a wide range of pharmacological options targeting different underlying mechanisms, such as improving insulin secretion, enhancing insulin sensitivity, delaying carbohydrate absorption, and promoting glucose excretion.

Among these therapeutic options, DPP-4 inhibitors, commonly referred to as “gliptins,” have gained considerable importance. These oral agents act by inhibiting the DPP-4 enzyme, thereby prolonging the activity of incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This results in improved glucose-dependent insulin release and reduced glucagon secretion, helping to achieve better glycemic control.

Over the past decade, DPP-4 inhibitors have been widely used due to their favorable safety profile and ease of administration. This review highlights their mechanism of action, clinical utility, and overall role in the comprehensive management of type 2 diabetes mellitus.
Keywords DPP-4 inhibitors; gliptins; type 2 diabetes mellitus; HbA1c; incretin; sitagliptin; vildagliptin; saxagliptin; linagliptin; alogliptin.
Field Medical / Pharmacy
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-12

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