International Journal For Multidisciplinary Research
E-ISSN: 2582-2160
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A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
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Volume 8 Issue 2
March-April 2026
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Utilization pattern of dipeptidyl peptidase IV inhibitors in diabetes mellitus patients
| Author(s) | Ms. Shaik Khamar E Azam, Dr.V.Satyanarayana, B.Lalitha Bai, T.Venu, Sk.Mahaboob Subhani |
|---|---|
| Country | India |
| Abstract | Type 2 diabetes mellitus is a rapidly growing global health concern, with its prevalence projected to increase significantly in the coming years. The disease is linked to multiple long-term complications that affect various organ systems, contributing to increased morbidity, mortality, and healthcare burden worldwide. Due to its multifactorial nature, management strategies for type 2 diabetes involve a wide range of pharmacological options targeting different underlying mechanisms, such as improving insulin secretion, enhancing insulin sensitivity, delaying carbohydrate absorption, and promoting glucose excretion. Among these therapeutic options, DPP-4 inhibitors, commonly referred to as “gliptins,” have gained considerable importance. These oral agents act by inhibiting the DPP-4 enzyme, thereby prolonging the activity of incretin hormones like glucagon-like peptide-1 (GLP-1) and glucose-dependent insulinotropic polypeptide (GIP). This results in improved glucose-dependent insulin release and reduced glucagon secretion, helping to achieve better glycemic control. Over the past decade, DPP-4 inhibitors have been widely used due to their favorable safety profile and ease of administration. This review highlights their mechanism of action, clinical utility, and overall role in the comprehensive management of type 2 diabetes mellitus. |
| Keywords | DPP-4 inhibitors; gliptins; type 2 diabetes mellitus; HbA1c; incretin; sitagliptin; vildagliptin; saxagliptin; linagliptin; alogliptin. |
| Field | Medical / Pharmacy |
| Published In | Volume 8, Issue 2, March-April 2026 |
| Published On | 2026-04-12 |
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E-ISSN 2582-2160
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IJFMR DOI prefix is
10.36948/ijfmr
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