A Comprehensive Review of the Therapeutic Potential of Boswellic Acid and Curcumin in Lung Cancer: Mechanistic Synergies, Pharmacological Advancements, and Translational Challenges

Author(s)	Mr. Dev Dipakkumar Soni, Ms. Suhani A Shah, Dr. Shailesh T Prajapati
Country	India
Abstract	Curcumin, derived from Curcuma longa (turmeric), and Boswellic Acid, obtained from Boswellia serrata (Indian frankincense), are bioactive phytochemicals with a well-documented history in traditional Indian medicine. Both compounds possess established anti-inflammatory and immunomodulatory properties directly relevant to cancer biology. This review examines preclinical and available clinical evidence on their individual and combined anti-lung-cancer activity, addresses bioavailability challenges, evaluates formulation strategies, and analyzes the existing translational gap. Curcumin inhibits proliferation in multiple NSCLC cell lines through suppression of PI3K/Akt/mTOR, STAT3, and NF-KB pathways. AKBA shows selective cytotoxicity against A549 cancer cells and inhibits oncogenic signaling through PI3K/Akt axis, G0/G1 arrest, and autophagy suppression. Co-administration produces synergistic cytotoxicity particularly in p53-mutated tumor backgrounds. Development of inhalable co-delivery systems and randomized controlled trials are the most urgent priorities.
Keywords	Boswellia Serrata, Curcuma Longa, Non-Small Cell Lung Cancer, Phytochemistry, Nanoparticle Delivery, PI3K/Akt/mTOR, NF-KB
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-04-16

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