International Journal For Multidisciplinary Research

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Volume 8 Issue 2
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One pot Synthesis of Phenyl-5-[2-(3-trifluoromethyl-phenyl)-vinyl]-[1, 3, 4] oxadiazole derivative under ultrasonic radiation”

Author(s) Dr. Shweta Vidhya Patwari, Dr. Sujata Sheshrao Patil, Dr. Shrikant G Kalane, Dr. Bharat Karbhari Dhotre
Country India
Abstract An efficient and environmentally benign ultrasound-assisted one-pot synthetic method has been developed for the preparation of Phenyl-5-[2-(3-trifluoromethyl-phenyl)-vinyl]-1,3,4-oxadiazole derivatives. The protocol involves the in situ condensation of substituted benzoic acid hydrazides with 3-(trifluoromethyl)benzaldehyde, followed by intramolecular cyclodehydration under ultrasonic irradiation. The application of ultrasound significantly enhances reaction kinetics through acoustic cavitation, resulting in reduced reaction time, improved yields, and cleaner reaction profiles compared to conventional heating methods. The synthesized oxadiazole derivatives were obtained in good to excellent yields and characterized by standard spectroscopic techniques such as FT-IR, ¹H NMR, ¹³C NMR, and mass spectrometry. The presence of the electron-withdrawing trifluoromethyl group is expected to enhance the physicochemical and biological properties of the synthesized compounds. This methodology demonstrates a green, rapid, and scalable approach for the synthesis of structurally diverse vinyl-substituted 1,3,4-oxadiazoles, aligning with current trends in sustainable heterocyclic chemistry. Ultrasound-assisted strategies have been widely reported to offer high efficiency, reduced energy consumption, and superior yields in oxadiazole synthesis. Additionally, one-pot cyclization of hydrazide-based intermediates remains a well-established route for constructing the 1,3,4-oxadiazole core.
Keywords One pot,1,3,4-oxadiazole, 3-(3-(trifluoro methyl) phenyl) acrylic acid, Ultrasonic radiation
Field Chemistry
Published In Volume 8, Issue 2, March-April 2026
Published On 2026-04-14
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