Salivary Cortisol Level Estimation in Patients with Oral Lichen Planus

SANJIB KUMAR KHATANIAR; ANJANA BAGEWADI

Salivary Cortisol Level Estimation in Patients with Oral Lichen Planus

Author(s)	Prof. Dr. SANJIB KUMAR KHATANIAR, Prof. Dr. ANJANA BAGEWADI
Country	India
Abstract	Background and Objective: Although Oral Lichen Planus (OLP) is a relatively common disorder, still the exact cause is remained unknown. Psychosomatic factors and their association with dermatological disorders are well recognized, yet their importance in OLP is debate. The purpose of this case–control study was to determine any possible association between stress and salivary cortisol levels in patients with OLP, who attended the outpatient department of Oral Medicine and Radiology, KLES’s Institute of Dental Sciences, Belgaum, Karnataka (India) during a period from 2003 to 2006. Materials and Methods: A total 80 subjects with different age and sex were included in the study into two groups i.e. Group A and Group B, where Group A is comprised of 40 subjects with clinically and histopathologically confirmed OLP and Group B is comprised of age and sex matched 40 normal healthy individuals. Saliva sample was collected from all the 80 subjects and samples were analyzed for the level of cortisol using Enzyme-Linked Immunosorbent Assay (ELISA) method and Stress levels of 80 patients were measured using the Presumptive Stressful Life Events Scale (PSLES). The readings from both Group A and Group B subjects were tabulated for statistical analysis. Results: The mean level of cortisol from 40 saliva samples in the study group was 6.68 ng/ml and 1.61 ng/ml in 40 controls (p<0.001). The mean score for PSLES in the study group were 321.4 and 183.3 in control group (p<0.001). We found that the salivary cortisol, levels, PSLES score in OLP group were significantly higher than in the control group. Interpretation and Conclusion: The present study revealed that the mean score of PSLES and the mean level of salivary cortisol of OLP patients were significantly higher as compared to the control group. Our findings concluded that OLP is closely related with stress. Thus besides traditional treatment of OLP, psychological support is also needed.
Keywords	Oral lichen planus; Stress; Salivary cortisol
Field	Medical / Pharmacy
Published In	Volume 8, Issue 2, March-April 2026
Published On	2026-04-14

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Salivary Cortisol Level Estimation in Patients with Oral Lichen Planus

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