International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 3
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Curcumin as a Natural Antifungal Agent: Mechanisms of Action, Formulation Strategies, and Therapeutic Potential

Author(s) Prof. Anjali Soni, Mr. Yash Panchali, Prof. Dr. Arun Kumar Gupta
Country India
Abstract Fungal infections have become a significant global health concern, particularly among immunocompromised individuals. The increasing prevalence of antifungal drug resistance and limitations associated with conventional antifungal therapies necessitate the exploration of alternative treatment strategies. Curcumin, a bioactive polyphenolic compound derived from Curcuma longa, has gained considerable attention due to its broad-spectrum pharmacological activities, including antimicrobial and antifungal effects.
This review aims to comprehensively evaluate the antifungal potential of curcumin, focusing on its mechanisms of action, formulation strategies, and therapeutic applications. Curcumin exhibits antifungal activity through multiple pathways, including disruption of fungal cell membrane integrity, inhibition of ergosterol biosynthesis, induction of oxidative stress, and inhibition of biofilm formation. However, its clinical utility is limited by poor aqueous solubility and low bioavailability.
To overcome these challenges, various advanced drug delivery systems such as nanoparticles, liposomes, nanoemulsions, and hydrogels have been developed, significantly enhancing its stability and therapeutic efficacy. The review also highlights the synergistic potential of curcumin with conventional antifungal agents.Overall, curcumin represents a promising natural antifungal agent, and further clinical studies are required to establish its safety and efficacy for therapeutic use.
Keywords Curcumin, Antifungal activity, Candida albicans, Nanoformulations, Bioavailability, Natural therapeutics, Ergosterol inhibition
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-13
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E-ISSN 2582-2160
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