International Journal For Multidisciplinary Research

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Association of HLA class I and class II genotyping in Autoimmune vesiculo-bullous lesion of skin

Author(s) Dr. Samaira Rawat, Arora N
Country India
Abstract Autoimmune vesiculo-bullous skin disorders are characterized by the presence of autoantibodies that target various intra- and extracellular components within the epidermis and at the basement membrane zone. The human leukocyte antigen (HLA), also known as the major histocompatibility complex, is essential for antigen processing and presentation, and typically shows highly significant correlations with autoimmune diseases.This observational case-control study comprised 37 clinically diagnosed cases of autoimmune inflammatory bullous disease (AIBD). Diagnosis was confirmed through punch biopsy, followed by histopathological analysis and direct immunofluorescence examination. Furthermore, HLA genotyping was conducted on these cases utilizing the PCR-SSOP method.The ages of the patients ranged from 3 to 80 years, with a significant female predominance (67.6%). Among the 37 cases, pemphigus vulgaris was the most common (48.6%), followed by bullous pemphigoid (18.9%), pemphigus foliaceus (13.5%), and dermatitis herpetiformis (10.8%). The HLA genotyping results revealed that within HLA class I, alleles HLA-A*03, A*29, and A*31; and B*52, along with HLA class II alleles HLA-DR*03, DR*11, DR*14, DR*15, and DRB5*, exhibited a stronger association with various AIBD cases.This study establishes a link between specific HLA class I and class II alleles and AIBDs within a North Indian population.
Keywords HLA class I and class II alleles, HLA genotyping, autoimmune vesiculo-bullous skin diseases, PCR-SSOP method
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-08
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E-ISSN 2582-2160
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