Physiological, Statistical, Psychological Characterisation of Gastrophageal Reflex Disease: Integrating Ph Monitoring, Manometric Techniques, and Stress Correlation

Author(s)	Ms. Kondra Ruhma, Dr. Dooslin Mercy Bai, Ms. Heena Thasneem
Country	India
Abstract	Gastroesophageal reflux disease (GERD) is a prevalent chronic gastrointestinal disorder traditionally attributed to acid reflux and lower esophageal sphincter dysfunction. Emerging evidence suggests that psychological stress significantly modulates symptom perception, disease severity, and treatment responsiveness through brain–gut axis mechanisms. This review aimed to synthesize current mechanistic and clinical evidence linking stress and GERD.
Keywords	Gastroesophageal reflux disease, psychological stress, brain–gut axis, visceral hypersensitivity, autonomic dysfunction, proton pump inhibitor resistance
Field	Medical / Pharmacy
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-06-11
DOI	https://doi.org/10.36948/ijfmr.2026.v08i03.77539

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