International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Phytochemical Screening and Pharmacological Profiling of Mabolo (Diospyros blancoi) Leaves and Stem Extract for Potential Therapeutic Application in Dermatology

Author(s) Ms. Tricia Loyola Restrivera, Prof. Virma De Lima Espejo
Country Philippines
Abstract Dermatological conditions such as acne, eczema, and microbial infections remain prevalent, prompting interest in safer plant-based alternatives. Diospyros blancoi has traditional dermatological uses but limited scientific validation. This study evaluated the phytochemical composition and pharmacological potential of Mabolo leaf and stem extracts for dermatological applications. Extracts were subjected to phytochemical screening and assessed for antioxidant (DPPH, ABTS, FRAP), anti-inflammatory (protein denaturation inhibition and membrane stabilization), and antimicrobial activities (agar diffusion, MIC, and MBC/MFC) against Staphylococcus aureus and Staphylococcus epidermidis. Statistical analyses included ANOVA and correlation tests at 0.05 significance level. The extracts contained flavonoids, tannins, saponins, terpenoids, and phenolics, which contributed to significant concentration-dependent antioxidant activity, notable anti-inflammatory effects, and antimicrobial inhibition. Statistical analysis showed significant differences among biological activities (F = 24.2054, p < 0.001) and varying correlations between antioxidant and pharmacological effects. Mabolo extracts exhibited significant antioxidant, anti-inflammatory, and antibacterial properties, supporting Diospyros blancoi as a promising natural candidate for dermatological and cosmeceutical applications.
Keywords mabolo, phytochemical analysis, antioxidant properties, anti-inflammatory effects, antimicrobial activity, dermatological applications
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-09
DOI https://doi.org/10.36948/ijfmr.2026.v08i03.77634
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