International Journal For Multidisciplinary Research

E-ISSN: 2582-2160     Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 3 (May-June 2026) Submit your research before last 3 days of June to publish your research paper in the issue of May-June.

Herbal Transdermal Drug Delivery Systems: Formulation Strategies and Evaluation of Aloe Vera-Based Therapeutic Patches

Author(s) KM Chanchal Chahar, Dr. Netra Pal Singh
Country India
Abstract Transdermal drug delivery systems (TDDS) have become one of the new and non-invasive methods of drug delivery to treat therapeutic agents, with benefits of increased bioavailability, controlled drug delivery and increased patient compliance. The introduction of herbal medicines in transdermal systems has gained prominence in recent years with the fact that they are safe, biocompatible, and with very minimal side effects. Aloe vera has been among the well-known medicinal plants with numerous pharmacological properties such as anti-inflammatory, antimicrobial, antioxidant and wound healing properties among others.
This review is an in depth examination of the design and testing of Aloe vera-based transdermal patches with a special focus on the theoretical basis of drug diffusion, skin permeability and controlled release systems based on polymers. The critical role of various elements of formulations, including polymers, plasticizers, and permeation enhancers is discussed in terms of its influence on drug release and patch performance. Different methods of preparation, especially the solvent casting method are discussed with major parameters of evaluation such as physical properties, uniformity of drug content and in vitro permeation studies.
In addition, the review points out the drug release mechanisms and kinetic models that have been used to understand and optimize transdermal delivery. The recent developments such as nanotechnology, liposomal systems, and microneedle-based methods are also discussed to identify its potential in overcoming the limitation of the traditional systems. Although issues of skin barrier properties, herbal extract variability, and stability can be problematic, new advances in the field of formulation science are leading to more effective and reliable systems.
In sum, transdermal patches containing Aloe vera are a potential combination of conventional herbal medicine and the latest drug delivery technology with promising potential to implement effectively and sustainably in curing therapeutic applications.
Keywords Aloe vera, Controlled drug release, Herbal drug delivery, Transdermal patches, Wound healing
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-11

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