International Journal For Multidisciplinary Research

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Volume 8 Issue 3
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A comparative study of Psoriasis vulgaris and Psoriasiform dermatitis variants on basis of Ki67, p53, cyclinD1, and VEGF immunohistochemical expression

Author(s) Dr. Samaira Rawat
Country India
Abstract BACKGROUND: Psoriasis is the prime example of psoriasiform tissue pattern and should be differentiated from other psoriasiform dermatoses both clinically and histopathologically, which is a diagnostic challenge, however, it has some implications for the patient’s management and prognosis.
AIM: To evaluate immunohistochemical expression of Ki67, p53, cyclinD1, and VEGF in psoriasis vulgaris and psoriasiform dermatoses for diagnostic purpose.
MATERIAL & METHODS: An analytical cross-sectional study was carried at Vardhman Mahavir Medical College & Safdarjung Hospital, New Delhi, India. Immunohistochemical stains for Ki67, p53, cyclin D1, and VEGF were performed on 24 cases including psoriasis vulgaris, chronic plaque psoriasis, plantar psoriasis, pustular psoriasis, guttate psoriasis, parapsoriasis, erythrodermal psoriasis, and rupioid psoriasis.
RESULT: There was no significant difference between psoriasis vulgaris and psoriasiform dermatoses groups in the result of Ki67. CyclinD1, and p53 distribution were also similar; however, there were a difference between the groups concerning cyclinD1 intensity which is higher in psoriasiform dermatoses than psoriasis vulgaris. VEGF staining showed a higher vascular proliferation in psoriasis vulgaris than in psoriasiform dermatoses groups.
CONCLUSION: The present study showed that Ki67, p53, and cyclinD1 aid in confirming the clinically and histopathologically diagnosed psoriasiform dermatitis cases. VEGF immunostaining shows a significantly more expressed vascular proliferation in psoriasis vulgaris patients, and can be helpful as immune marker for differentiating psoriasis vulgaris and psoriasiform dermatoses group.
Keywords psoriasiform dermatoses, Ki67, p53, VEGF, cyclinD1
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-17
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