Cheminformatic Tools to Evaluate Drug-protein Interactions and Observe Structure-activity Relationships to Identify New Molecular Entities for the Treatment of Uveitis

Ruchika Singh Jaral

Cheminformatic Tools to Evaluate Drug-protein Interactions and Observe Structure-activity Relationships to Identify New Molecular Entities for the Treatment of Uveitis

Author(s)	Dr. Ruchika Singh Jaral
Country	India
Abstract	Ocular diseases are those diseases that affect the eyes, according to recent data, globally 2.2 billion people have vision impairment and half of them have a type which was preventable or is yet to be addressed. Ocular diseases are categorised into two types on the basis of their target regions in the eyes: Anterior segment ocular diseases that affect the anterior portion of the eye which includes the cornea, iris, ciliary body and lens, such as dry eye, conjunctivitis, blepharitis, cataract, glaucoma etc & Posterior segment eye diseases that affect the retina, choroid and optic nerve such as optic neuritis, macular degeneration, retinal detachment, intravenous haemorrhage etc. While some types are milder ones that do not cause much harm to the eyes, many of these pose serious threats which may also include the permanent loss of vision along with other complications such as damage to the optic nerve, deformation of lens, damage to the retina etc. Uveitis is a rare disease that affects the uvea part of the eye, its possible causes include infection injury or an autoimmune or inflammatory disease, in a paediatric case study extraocular Staphylococcus aureus infection was shown to have triggered the reactivation of autoimmune ocular inflammation thereby causing autoimmune uveitis. Hence, there is ongoing research to come out with solutions that could help to treat or prevent this disease. Oxazolidinones are a class of drugs that treat bacterial infections, its first compound is Linezolid which was approved by FDA in 1999. It targets diseases caused by gram-positive bacteria, it works by inhibiting the process of translation after binding to the rRNA. Several other drugs are available worldwide whose potential effects for other diseases apart from the ones that they mainly treat are yet to be discovered.
Keywords	MOLECULAR MODELLING, AUTODOCK VINA1.2.41, CADD, THEORETICAL AND COMPUTATIONAL CHEMISTRY, ORGANIC CHEMISTRY, LINEZOLID, OXAZOLIDINONES, PDB DRUGBANK, ENERGY MINIMISATION, PHARMACOLOGY, PHARMACOKINETICS, MEDICNE, PROTEIN MACHINERY, TARGET PROTEIN 6WRS, CHEMDRAW28.0, , OPENBBABEL, AVOGADRO47.0, PYRX LITE, BIOVIA DISCOVERY STUDIO, SWISSADME 33.0, GAUSSIAN, PYMOL , ETC ETC
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-19

View / Download PDF File

E-ISSN 2582-2160

doi

CrossRef DOI is assigned to each research paper published in our journal.

IJFMR DOI prefix is
10.36948/ijfmr

Downloads

Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 8 Isu 3 Cover Page Vol 8 Isu 2 Cover Page Vol 8 Isu 2

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA

About IJFMR Fees & Payment Current Issue Publication Archive	Submit Research Paper Track Submission Status Publication Guidelines Publication Ethics Peer Review & Plagiarism	Join as a Reviewer Editors & Reviewers Reviewer Referral Program Get Reviewer Membership Certi.	Website/Journal Policies Usage Policy Content Policies Privacy Policy

Contact Us		+91-9687-828-838	editor@ijfmr.com

International Journal For Multidisciplinary Research

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Cheminformatic Tools to Evaluate Drug-protein Interactions and Observe Structure-activity Relationships to Identify New Molecular Entities for the Treatment of Uveitis

Share this