International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 3
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Impact Of Pharmaceutical Care Interventions On Medication Adherence, Clinical Outcomes, And Quality Of Life In Coronary Heart Disease Patients: A Prospective Interventional Study

Author(s) Ms. KM Khushboo Chauhan, Ms. Shalu Singh
Country India
Abstract Coronary heart disease (CHD) is one of the leading causes of morbidity and mortality worldwide and continues to represent a major public health burden, particularly in developing countries such as India. Poor medication adherence, polypharmacy, inadequate patient education, and lifestyle-related risk factors significantly affect therapeutic outcomes and quality of life among CHD patients. Pharmaceutical care interventions provided by clinical pharmacists may improve medication adherence, optimize clinical outcomes, and enhance patient-centered care. The present study was conducted to evaluate the impact of pharmaceutical care interventions on medication adherence, clinical outcomes, and quality of life among coronary heart disease patients attending a tertiary care teaching hospital. A prospective interventional study was carried out among 120 coronary heart disease patients receiving cardiovascular medications. Data regarding demographic characteristics, comorbid conditions, medication utilization patterns, medication adherence, clinical parameters, quality of life, and drug-related problems were collected using a structured data collection form. Pharmaceutical care interventions including medication review, patient counseling, medication adherence education, lifestyle modification counseling, adverse drug reaction monitoring, and follow-up support were provided throughout the study period. Clinical outcomes before and after intervention were statistically analyzed. The majority of patients belonged to the age group of 51–60 years and male predominance was observed among the study population. Hypertension (72.5%), dyslipidemia (61.7%), and diabetes mellitus (48.3%) were identified as the major associated comorbid conditions. Significant improvement in medication adherence was observed following pharmaceutical care intervention. Mean systolic blood pressure reduced from 154.8 ± 12.4 mmHg to 132.5 ± 8.6 mmHg, while LDL cholesterol reduced from 164.2 ± 21.5 mg/dL to 118.6 ± 16.4 mg/dL. Significant improvement was also observed in blood glucose levels, body mass index, and quality-of-life scores (p < 0.05). Medication non-adherence, adverse drug reactions, and drug-drug interactions were among the most commonly identified drug-related problems during the study period. The study concluded that pharmaceutical care interventions provided by clinical pharmacists significantly improved medication adherence, clinical outcomes, and quality of life among coronary heart disease patients. The findings strongly support integration of structured pharmaceutical care services into routine cardiovascular healthcare practice for achieving improved patient-centered therapeutic outcomes.
Keywords Clinical Outcomes, Clinical Pharmacist, Coronary Heart Disease, Drug-Related Problems, Medication Adherence, Pharmaceutical Care, Polypharmacy, Quality of Life
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-19
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E-ISSN 2582-2160
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