International Journal For Multidisciplinary Research

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Contemporary Advances In Non-Fluoridated Remineralizing Agents : A Literature Review

Author(s) Dr. Manjari Pandian, Dr. Pradeep Daniel Gainneos, Dr. Devadhakshayani Venkatesan, Dr. Muthusri B, Dr. Ekta Manohar Pendurkar
Country India
Abstract Background: Dental caries is a dynamic process involving cycles of demineralization and remineralization. With advances in dental science, the focus has shifted from restorative treatment to early diagnosis and minimally invasive management. Limitations of fluoride such as fluorosis risk and limited penetration into deeper lesions have increased interest in non-fluoride remineralizing agents that supply bioavailable calcium and phosphate and support natural enamel repair.
Aim: This review aims to explore the potential of non-fluoride remineralizing agents in the management of early dental caries, highlighting their mechanisms, types, and clinical relevance.
Materials and Methods: A comprehensive literature search was conducted using PubMed, Google Scholar, and Scopus. Studies evaluating calcium phosphate systems, bioactive glasses, natural agents, and peptides in enamel remineralization were included.
Results: Non-fluoride agents such as CPP-ACP, bioactive glass, nano-hydroxyapatite, and DCPD exhibit effective remineralization potential. Many mimic natural enamel processes and offer advantages over fluoride, including reduced toxicity and improved subsurface penetration.
Conclusion: Non-fluoride agents are promising alternatives to fluoride in early caries management, especially in fluoride-sensitive individuals. Further long-term clinical studies are required to establish standardized treatment protocols.
Clinical Significance: Non-fluoride remineralizing agents support minimally invasive caries management by enhancing natural enamel repair and reducing the need for restorative treatment. They are particularly beneficial for high-risk, fluoride-sensitive, and pediatric populations, offering safe and effective options for early caries reversal.
Keywords Dental caries, Remineralization, Non-fluoride agents, CPP-ACP
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-18
DOI https://doi.org/10.36948/ijfmr.2026.v08i03.78771
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