Maternal and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study from a Tertiary Care Centre

Priya Garhwal; Neelam Swaroop; Charu Yadav; Parul Verma

doi:10.36948/ijfmr.2026.v08i03.78962

Maternal and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study from a Tertiary Care Centre

Author(s)	Dr. Priya Garhwal, Prof. Dr. Neelam Swaroop, Dr. Charu Yadav, Dr. Parul Verma
Country	India
Abstract	Background Intrahepatic cholestasis of pregnancy (IHCP) is the most common pregnancy-specific liver disorder, characterized by pruritus and elevated serum bile acids, and is associated with adverse maternal and perinatal outcomes. Despite increasing recognition, regional data regarding its clinical spectrum and outcomes remain limited. This study aimed to evaluate maternal complications and perinatal outcomes in antenatal women diagnosed with IHCP at a tertiary care centre. Methods A prospective observational study was conducted over 18 months [January 2024 – June 2025] at T.S. Misra Medical College and Hospital, Lucknow. A total of 100 antenatal women diagnosed with IHCP based on clinical features and biochemical parameters (serum bile acids >10 μmol/L and/or abnormal liver enzymes) were included. Ethical approval was obtained from the Institutional Ethics Committee, and the study adhered to the Declaration of Helsinki. All patients received ursodeoxycholic acid and were monitored with fetal surveillance protocols including cardiotocography and biophysical profile. Data were analyzed using SPSS version 29.0, with statistical significance set at p<0.05. Results The mean maternal age was 30.53 ± 5.46 years, with 59% primigravida. Pruritus was the most common symptom (86%). Higher serum bile acid levels (>60 μmol/L) were significantly associated with adverse outcomes, including meconium-stained amniotic fluid (81.8%), fetal distress (81.8%), respiratory distress syndrome (72.7%), preterm delivery (54.5%), NICU admission (100%), and intrauterine death (27.3%) (p≤0.031). Mean birth weight was significantly lower in the high bile acid group (p=0.017). Conclusion IHCP is associated with significant maternal and perinatal morbidity, especially at higher serum bile acid levels. Serum bile acids serve as a reliable predictor of adverse outcomes, emphasizing the need for early diagnosis, close monitoring, and timely intervention
Keywords	Intrahepatic cholestasis of pregnancy, serum bile acids, pruritus, perinatal outcomes, preterm delivery, fetal distress
Field	Medical / Pharmacy
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-19
DOI	https://doi.org/10.36948/ijfmr.2026.v08i03.78962

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Maternal and Perinatal Outcomes in Intrahepatic Cholestasis of Pregnancy: A Prospective Observational Study from a Tertiary Care Centre

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