International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 3
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High-grade B-cell non-Hodgkin’s lymphoma of the thyroid gland mimicking Hashimoto’s thyroiditis: A diagnostic challenge.

Author(s) Dr. Shikha Jayesh Shah, Prof. Dr. Jasmin Jasani, Dr. Trupti R. Jansari, Dr. Simran Jain
Country India
Abstract Primary thyroid lymphoma (PTL) is a rare malignancy that has been estimated to constitute approximately 1%-5% of thyroid malignancies and 1%-2% of extranodal lymphomas, Different subtypes of lymphoma can present as primary thyroid lymphoma. Here we represent a case of a 57 years old female patient with complaints of midline neck swelling since 6 months which moves with deglutition and does not move with tongue protrusion. Sonography was suggestive of thyroiditis. FNAC report was given as Bethesda Il: Features were suggestive of colloid goiter with nonspecific thyroiditis. Patient had undergone total thyroidectomy surgery and the specimen was received in our histopathology department. The representative sections were stained with hematoxylin and eosin ( H & E) stain. Microscopic examination showed microfollicles and macro follicles filled with colloid. There was presence of lymphoid aggregates with prominent germinal center and diffusely infiltrating the thyroid parenchyma. Few follicles showed prominent hurthle cell changes and some of which showed atrophy.At places, the cells were arranged in discohesive pattern. The cells showed moderate pleomorphism irregular nuclear border and moderate amount of eosinophilic cytoplasm. At places, mitotic figures was seen. For further confirmatory IHC panel was kept and the tumours stained positive for CD45 and CD5 while the thyroid follicles stained positive for TTF-1 so the final diagnosis of high grade Non Hodgkins lymphoma was given.
Keywords Key words: NHL, midline neck swelling, hashimoto’s thyroiditis.
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-05-23
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E-ISSN 2582-2160
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