Formulation Development and Evaluation of a Polyherbal Antioxidant Drug Derived from Asparagus

Mahesh Pradiprao Junghare; Priya M Dandekar; Akshay G Ghule; Amol G Jadhao

Formulation Development and Evaluation of a Polyherbal Antioxidant Drug Derived from Asparagus

Author(s)	Mr. Mahesh Pradiprao Junghare, Prof. Priya M Dandekar, Prof. Akshay G Ghule, Prof. Amol G Jadhao
Country	India
Abstract	Introduction Polyherbal formulations, which leverage the synergistic effects of multiple plant extracts, have garnered significant attention in pharmaceutical development due to their multifaceted therapeutic potential (Rathod & Aswar, 2025; Surana et al., 2023). This approach aligns with traditional medicinal systems such as Ayurveda, where complex plant combinations are utilized to restore physiological balance and address underlying disease etiologies (Kotmire et al., 2024). One such revered botanical, Asparagus racemosus, is particularly noted for its adaptogenic and antioxidant properties, making it a compelling candidate for incorporation into novel polyherbal drug formulations (Sunte et al., 2023). The development of such formulations necessitates rigorous pre-formulation studies to assess the physical parameters, stability, and compatibility of individual extracts with excipients, ensuring optimal drug delivery and therapeutic efficacy (Ramachandran et al., 2025; Tungadi & Putri, 2025). These investigations are crucial for characterizing parameters such as angle of repose, compressibility index, and Hausner ratio, which dictate powder flow properties essential for successful manufacturing processes like encapsulation or tablet compression (Mahto et al., 2022). Moreover, comprehensive organoleptic and macroscopic analyses are routinely performed to ensure the quality and consistency of raw herbal materials, evaluating characteristics such as color, odor, taste, shape, and texture (K & K, 2021). Beyond macroscopic evaluation, detailed phytochemical analysis is indispensable for identifying and quantifying the bioactive compounds responsible for the therapeutic effects (Prathyusha, 2022). This includes preliminary phytochemical screening for major classes of compounds such as flavonoids, alkaloids, and phenolic acids, often followed by advanced spectroscopic and chromatographic techniques for detailed fingerprinting and quantification (Gupta et al., 2022). Subsequently, the polyherbal extracts undergo in vitro pharmacological assessments, including free radical scavenging assays such as DPPH, ABTS, and hydrogen peroxide radical scavenging, to quantify their antioxidant capacity (Khan et al., 2021).
Keywords	Polyherbal Antioxidant, Antioxidant Asparagus , aspuragus resimosus
Field	Medical / Pharmacy
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-26

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Formulation Development and Evaluation of a Polyherbal Antioxidant Drug Derived from Asparagus

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