Development and Evaluation of Dual-responsive Curcumin Nanoemulgel for Enhanced Topical Delivery and Anti-inflammatory Activity

Author(s)	Mr. Chetan Rajendra Jadhav, Mr. Ghanshyam Trambak Gangurde, Mr. Rushikesh Popat Mahale, Ms. Rutuja Sharad Gunjal, Ms. Komal Dadaji Jadhav
Country	India
Abstract	This study aimed to develop a dual responsive curcumin nanoemulgel for effective treatment of skin inflammation with controlled drug release. Curcumin, a natural compound with anti-inflammatory and antioxidant properties, has low solubility and poor bioavailability, which was improved using a nanoemulgel system. The nanoemulsion was prepared using oil, surfactant, co-surfactant, and water, then incorporated into a gel base. The formulation was evaluated for physical properties, pH, viscosity, spreadability, drug content, particle size, zeta potential, drug release, skin permeation, anti-inflammatory activity, and stability. Results showed good stability, uniformity, suitable pH, nanosized droplets, and sustained drug release with enhanced skin permeation. The formulation also demonstrated significant anti-inflammatory activity. Overall, dual responsive curcumin nanoemulgel proved to be a promising topical delivery system for improved treatment of skin inflammation.
Keywords	Curcumin, Nanoemulgel, Skin inflammation, Controlled drug release, Topical delivery, Nanoemulsion, Anti-inflammatory.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-29

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