Electrophoretic Analysis of Seminal LDH Isoenzyme Activity in Male Swiss Albino Mice Treated with Aqueous Seed Extract of Foeniculum Vulgare

Author(s)	Mr. Anand kumar, Ms. Roushni parween
Country	India
Abstract	The present study was designed to evaluate the antifertility effect of aqueous seed extract of Foeniculum vulgare on seminal lactate dehydrogenase (LDH) isoenzyme activity in male Swiss albino mice using electrophoretic techniques. A total of 54 healthy male Swiss albino mice were divided into three groups consisting of control, low dose, and high dose treated animals. The aqueous seed extract was administered orally for 15, 30, and 45 days. Electrophoretic analysis revealed significant alterations in LDH isoenzyme patterns in treated groups. LDH-1, LDH-2, and LDH-3 activities gradually decreased with increasing duration and dose of treatment, whereas LDH-4 and LDH-5 activities increased markedly. A significant reduction in LDH-C4 activity was observed in both treatment groups, indicating impairment of sperm-specific metabolic activity. The findings suggest that aqueous seed extract of Foeniculum vulgare adversely affects seminal metabolism and may contribute to antifertility effects in male mice.
Keywords	Keywords: Foeniculum vulgare, LDH isoenzymes, electrophoresis, antifertility, seminal plasma, Swiss albino mice.
Field	Biology > Zoology
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-29
DOI	https://doi.org/10.36948/ijfmr.2026.v08i03.79879

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