The Metabolic Axis in Subclinical Hypothyroidism: A Comparative Scientific Review of Conventional Endocrinology and Classical Ayurveda

Author(s)	Dr. ITIKA PAMNANI, Prof. GULAB CHAND PAMNANI, Dr. HEMANT KUMAR NAGAR
Country	India
Abstract	Subclinical Hypothyroidism (SCH) represents a critical biochemical state characterized by compensated thyroid failure. In modern endocrinology, it is defined by elevated serum Thyroid-Stimulating Hormone (TSH) levels paired with normal circulating free thyroxine (T-4) and triiodothyronine (T-3) levels in asymptomatic or mildly symptomatic individuals. From an Ayurvedic perspective, SCH cannot be reduced to a single disease entity but correlates closely with Mandagni (diminished metabolic fire) and Agnimandhya. The classical framework views this pathology as a dynamic state of Doshic disequilibrium, primarily involving Vata-Kapha dominance with an associated depletion of Pitta (Pitta Kshaya). This review provides a rigorous, comprehensive scientific synthesis of the anatomy, physiology, pathophysiology, and therapeutic interventions of SCH by bridging contemporary endocrine science with classical Ayurvedic principles based on established literature.
Keywords	Subclinical Hypothyroidism, Mandagni, Agnimandhya, HPT Axis, Jatharagni, Dhatvagnimandya, Integrated Medicine.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 3, May-June 2026
Published On	2026-05-29
DOI	https://doi.org/10.36948/ijfmr.2026.v08i03.79907

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