International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 4
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Health-Related Quality of Life in Chronic Kidney Disease: A Comprehensive Review

Author(s) Prof. Dr. DANISHA PATTANI, Ms. SHANU JAS KARUNAKARATH, Mr. JASEEL UPPOODAN
Country India
Abstract Chronic kidney disease (CKD) is a progressive non-communicable disorder that significantly affects the health-related quality of life (HRQOL) of affected individuals. As the global burden of CKD continues to rise, increasing impairment in kidney function contributes to a wide range of physical, psychological, and social challenges that are not fully reflected by conventional clinical and laboratory parameters. This review provides a comprehensive overview of current evidence on HRQOL in CKD, focusing on its assessment, determinants, clinical significance, and strategies for improvement. Available evidence indicates that HRQOL declines progressively with advancing disease severity and is adversely influenced by factors such as reduced kidney function, anaemia, hyperphosphataemia, hypoalbuminaemia, comorbid conditions, and psychological distress. Impairment is generally more pronounced in physical health domains than in mental health domains. Among the available assessment instruments, disease-specific tools such as the Kidney Disease Quality of Life-36 (KDQOL-36) demonstrate greater sensitivity in capturing the unique burden of CKD. Patients receiving haemodialysis consistently report poorer HRQOL than those in earlier stages of the disease, while evidence suggests that deterioration in quality of life often begins before the initiation of dialysis. Interventions including structured exercise programmes, psychological support, nutritional management, optimisation of anaemia treatment, and multidisciplinary care have shown potential to improve patient-reported outcomes. Overall, HRQOL represents an important patient-centred outcome that complements traditional clinical measures and provides valuable prognostic information. Greater integration of routine HRQOL assessment, patient-reported outcome measures, and targeted supportive interventions into CKD care may contribute to improved patient well-being and healthcare outcomes, particularly in resource-limited settings.
Keywords Chronic kidney disease 1, Health-related quality of life 2, KDQOL-36 3, SF-36 4, EQ-5D 5, Anaemia 6, Depression 7, Dialysis 8, eGFR 9
Field Medical / Pharmacy
Published In Volume 8, Issue 3, May-June 2026
Published On 2026-06-11
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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