International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 4 (July-August 2026) Submit your research before last 3 days of August to publish your research paper in the issue of July-August.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 4
July-August 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Primary Biliary Cholangitis Presenting as Decompensated Cirrhosis with Hepatic Encephalopathy in a Young Female: A Case Report

Author(s) Dr. PRIYADARSHINI MJ, Prof. Dr. SHANTHI B, Prof. Dr. RADHALAKSHMI P
Country India
Abstract Background: Primary Biliary Cholangitis (PBC) is a chronic, progressive autoimmune cholestatic liver disease predominantly affecting middle-aged women, characterised by immune-mediated destruction of small intrahepatic bile ducts leading to cholestasis, fibrosis, and cirrhosis. The anti-mitochondrial antibody (AMA), positive in over 95% of cases, is its serological hallmark. Rapid decompensation in younger patients with hepatic encephalopathy is uncommon and clinically challenging.
Case Summary: We report a 41-year-old female diagnosed with PBC (ANA positive, AMA positive at titre 1:100 by IFA) who presented in June 2026 with acute decompensation: drowsiness, bilateral pedal oedema, decreased urine output, vomiting, and Grade III hepatic encephalopathy. Investigations revealed severely deranged liver function (total bilirubin 25.16 mg/dL), coagulopathy (INR 2.91), hypoalbuminemia (albumin 2.1 g/dL), hyponatraemia (Na 129 mEq/L), hypokalaemia (K 1.9 mEq/L), gross splenomegaly, and moderate ascites. Fibroscan showed LSM 53 kPa confirming cirrhosis. ICU management included albumin infusion, diuretics, lactulose, rifaximin, LOLA/Heparmerz, BCAA supplementation, blood products, and antibiotics. The patient had previously been advised liver transplantation.
Conclusion: This case highlights the critical importance of early AMA screening in young women with cholestatic liver disease, timely initiation of ursodeoxycholic acid (UDCA), and early transplant listing in PBC. Rapid disease progression to decompensated cirrhosis underscores the need for vigilant follow-up.
Keywords Primary Biliary Cholangitis; Antimitochondrial Antibody; Hepatic Encephalopathy; Decompensated Cirrhosis; Autoimmune Liver Disease; Splenomegaly; Liver Transplantation; Fibroscan
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-07-12
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form Cover Page Vol 8 Isu 4Cover Page Vol 8 Isu 3Cover Page Vol 8 Isu 2

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com
Powered by Sky Research Publication and Journals