International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 4
July-August 2026

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“Machine Perfusion for Liver Preservation: Technologies and Translational Advances”

Author(s) Deveshkumar Mahendralal Kothwala, Mr. Rahul, Ms. Shreya Maheshbhai
Country India
Abstract Abstract
Liver transplantation remains the definitive treatment for end-stage liver disease; however, preservation strategies critically influence graft viability and post-transplant outcomes. Conventional static cold storage (SCS) is limited by the inability to provide metabolic support or assess organ function prior to transplantation. Machine perfusion (MP) has emerged as a transformative technology enabling continuous oxygenation, nutrient delivery, and real-time viability assessment. This review evaluates the current state of liver perfusion technologies, including hypothermic, subnormothermic, and normothermic perfusion approaches. A structured literature analysis was performed to assess technological evolution, clinical outcomes, and regulatory considerations. Key findings indicate that MP improves graft utilization, reduces ischemia-reperfusion injury, and enables functional assessment through biomarkers such as lactate clearance, bile production, and mitochondrial indicators. Reported clinical benefits include reduced biochemical graft injury, reduced post-transplant AST/ALT release in selected studies, improved lactate clearance, increased bile production, lower early allograft dysfunction, extended preservation time, and improved utilization of extended criteria donor livers. Despite promising outcomes, challenges remain in standardization, cost, infrastructure requirements, training, and integration into clinical workflows. Future directions include multi-modal perfusion strategies, real-time metabolic sensing, biosensor integration, artificial intelligence-based viability prediction, and portable perfusion systems for broader clinical adoption. This review provides a comprehensive overview of current technologies and highlights pathways for translational advancement.
Keywords Keywords: Machine perfusion, Liver preservation, Normothermic perfusion, Hypothermic perfusion, Organ viability, Transplantation, Ex vivo perfusion, Ischemia-reperfusion injury
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-08-14
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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