International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Teduglutide Attenuates Atherosclerosis via GLP-2R–Mediated Intestinal Barrier Protection in High Fat Diet Rats

Author(s) Ms. Mandeep Kaur, Ms. Gazal Ansari, Mr. Satyam Khajuria, Ms. Kiran Khanna
Country India
Abstract Atherosclerotic cardiovascular disease (ASCVD) remains a major cause of morbidity and mortality despite effective lipid-lowering and antithrombotic therapies, indicating persistent residual risk driven by chronic inflammation, endothelial dysfunction, and the gut–vascular axis. Disruption of intestinal barrier integrity facilitates translocation of microbial products, systemic endotoxemia, and low-grade inflammation that accelerate atherogenesis. Glucagon-like peptide-2 (GLP-2), acting through the GLP-2 receptor (GLP-2R), enhances mucosal growth, tightens junctions, and reduces intestinal permeability. Teduglutide, a long-acting GLP-2 analog approved for short bowel syndrome, has not been systematically evaluated for cardiovascular protection in atherosclerosis models. This study will examine the effect of teduglutide-mediated GLP-2R activation on vascular inflammation, endothelial function, and plaque development in high-fat diet-fed rat by assessing aortic plaque burden, vascular reactivity, inflammatory and oxidative stress markers, endotoxin levels, and gut permeability. We hypothesise that teduglutide will strengthen the intestinal barrier, reduce endotoxemia and systemic inflammation, and thereby attenuate endothelial dysfunction and atherosclerosis progression, providing in vivo evidence that targeting the GLP-2R–gut barrier axis is a novel therapeutic strategy in ASCVD.
Keywords Teduglutide, GLP 2 receptor (GLP 2R), Intestinal barrier integrity, Atherosclerosis
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-07-14
DOI https://doi.org/10.36948/ijfmr.2026.v08i04.83846
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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