International Journal For Multidisciplinary Research

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Volume 8 Issue 4
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Homoeopathic Susceptibility and Modern Biomedicine: A Conceptual Reappraisal Through Immunology, Epigenetics, Psychoneuroimmunology, and Systems Biology

Author(s) Dr. Srikar Thota
Country India
Abstract Background: The classical homoeopathic concept of susceptibility, first articulated by Samuel Hahnemann in the Organon of Medicine, proposed that disease cannot manifest in any organism unless that organism possesses an internal receptivity to receive it. Written before the existence of immunology, genetics, or microbiology, this framework represented a prescient attempt to explain why individuals exposed to identical pathogenic stimuli respond in radically different ways.

Objective: To critically examine the classical construction of susceptibility across major homoeopathic philosophers, trace its conceptual evolution, and systematically compare it with evidence-based frameworks in immunology, molecular genetics, epigenetics, psychoneuroimmunology (PNI), and systems biology.

Methods: A narrative integrative review was conducted using primary homoeopathic texts (Hahnemann, Kent, Close, Roberts) and peer-reviewed literature indexed in PubMed, Scopus, and Web of Science (1990-2025). Conceptual parallels were drawn while rigorously distinguishing analogy from mechanistic equivalence.

Results: Classical susceptibility maps onto several modern constructs: host-response variability in innate and adaptive immunity, HLA-linked and polygenic disease predisposition, epigenetic modulation of gene expression, neuroendocrine-immune axis dysregulation, and network-based homeostatic resilience. Constructions such as vital force and miasmatic theory remain outside current empirical validation.

Conclusion: Susceptibility may be productively reinterpreted as a systems-level construct reflecting dynamic neuro-immuno-endocrine responsiveness shaped by genetic, epigenetic, and environmental determinants. Conceptual convergence does not imply therapeutic equivalence; interdisciplinary dialogue grounded in methodological rigour explains a productive frontier for integrative research.
Keywords Homoeopathic Susceptibility, Host Variability, Vital Force, Psychoneuroimmunology, Epigenetics, Systems Biology, Integrative Medicine, Miasmatic Theory
Field Biology > Medical / Physiology
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-07-22
DOI https://doi.org/10.36948/ijfmr.2026.v08i04.84287
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