International Journal For Multidisciplinary Research

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Effect of Proprioceptive Neuromuscular Facilitation on Pain, Fatigue, Severity, and Functional Independence In Acute Guillain-Barré Syndrome: An Interventional Study

Author(s) Dr. Latasha Ahuja, Dr. Megha Gakhar, Prof. Dr. Surekha Dabla, Dr. Bhawna Verma, Prof. Dr. Vinay Jagga, Dr. Soumya Khanagwal
Country India
Abstract Introduction: Guillain-Barré syndrome (GBS) is an acute immune-mediated neuropathy causing weakness, pain, fatigue, and functional decline. Evidence comparing structured physiotherapy approaches during acute hospitalization remains limited. This study compared the effects of Proprioceptive Neuromuscular Facilitation (PNF) with conventional physiotherapy on pain, fatigue, disease severity, and functional independence in acute GBS.
Materials and Methods: A randomized controlled trial was conducted in a tertiary care hospital. Thirty-two patients with acute GBS were randomized to PNF (n = 16) or conventional physiotherapy (n = 16). Outcomes including pain, fatigue, disease severity, and functional independence were assessed using the Numeric Pain Rating Scale, Fatigue Severity Scale, Hughes Functional Grading Scale, and Barthel Index at admission, two weeks, and discharge. The Friedman test, Wilcoxon signed-rank test with Bonferroni correction, and Mann-Whitney U test were applied for within-group, post-hoc pairwise, and between-group comparisons, respectively.
Results: Both groups demonstrated significant improvement across all outcome measures over time (p < 0.001). Fatigue at discharge was significantly lower in the PNF group (p = 0.004). Change-score analysis favored PNF for pain and fatigue reduction, though between-group differences were not statistically significant for most outcomes.
Conclusions: Early structured physiotherapy during acute hospitalization improves pain, fatigue, disease severity, and functional independence in GBS. PNF is comparable to conventional physiotherapy and may offer additional benefit in reducing fatigue during early recovery.
Keywords Guillain-Barré Syndrome, early physiotherapy, proprioceptive neuromuscular facilitation
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-07-26
DOI https://doi.org/10.36948/ijfmr.2026.v08i04.84448
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