International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 4 (July-August 2026) Submit your research before last 3 days of August to publish your research paper in the issue of July-August.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 4
July-August 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

THE JOINT-GUT AXIS: SYSTEMIC TRANSLOCATION OF INGESTED PLASTICS TO JOINT SPACES

Author(s) Mr. Karthikeyan Ganesamoorthi
Country India
Abstract The spread occurrence of micro and nanoplastics in food and potable water raises serious concerns about their health effects. The growing evidence points to the gastrointestinal tract being the main entry point for these small particles that initiate a cascade of reactions that go far beyond mild gastrointestical discomfort and ingestion, microplastics trigger oxidative stress responses, disrupt epithelial integrity, impair barrier function, and dysregulate the gut microbiota host dialogue. The gut microbiota is followed by increased intestinal permeability and entry of plastic particles into systemic circulation, either through the hepatic portal vein or lymphatic system, and activation of gut-associated lymphoid tissue. The activation of the inflammasome and increases the quantity of pro-inflammatory cytokines in the inflamed intestine. Monocytes, macrophages, and dendritic cells enter the blood circulation and invade the inflamed, fibrotic, and eroded joints, then the synovial cells, macrophages, osteoblasts, and chondrocytes ingest plastic material. In the joint, the presence of foreign material causes oxidative stress, activation of the inflammasome, and activation of metalloproteinases that lead to the destruction of cartilage, dysfunction of chondrocytes, and pathological remodeling of bone. In microplastics appear to be involved in a process that starts in the gastrointestinal tract and contributes to persistent inflammation of the joints. The mechanisms by which diet-derived plastics influence the gut microbiota-host immune interactions is critical for furthering the understanding of how microplastics affect the etiology and pathogenesis of joint diseases.
Keywords Joint-Gut Axis, Microplastics Translocation, Barrier Compromise, Intestinal Dysbiosis, Lymphatic Bypass, Monocyte Priming
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-08-07
DOI https://doi.org/10.36948/ijfmr.2026.v08i04.85195
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com
Powered by Sky Research Publication and Journals