International Journal For Multidisciplinary Research

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Antiviral Activity of Synthetic Bis-Naphthoquinone (H-5) Against Chikungunya Virus Replication

Author(s) Ms. Lavanya HN, Ms. Pravalika KM, Dr. sunil kumar busi, Dr. Gopinatha Elumalai
Country India
Abstract Chikungunya virus (CHIKV) is a mosquito-borne alphavirus that has emerged as a major global public health concern due to its rapid spread and the absence of specific antiviral therapies. Infection with CHIKV commonly causes high fever, severe polyarthralgia, myalgia, headache, and skin rash, with joint pain often persisting for months or years, significantly affecting the quality of life of infected individuals. Although supportive care remains the primary treatment option, the growing burden of chikungunya has emphasized the need for the development of safe and effective antiviral agents. Among various compounds investigated, naphthoquinone derivatives have attracted considerable attention because of their broad-spectrum biological activities, including antiviral, antibacterial, antifungal, antiparasitic, anticancer, and anti-inflammatory properties.
Synthetic bis-naphthoquinone (H-5) has recently emerged as a promising antiviral candidate against CHIKV. Experimental studies have demonstrated that H-5 effectively inhibits viral replication in infected cells while exhibiting comparatively low cytotoxicity toward host cells. In addition, preclinical investigations suggest that H-5 can reduce viral load and improve disease outcomes in animal models. The antiviral effect of H-5 is believed to result from interference with critical stages of the viral replication cycle, making it a potential lead molecule for the development of novel anti-chikungunya therapeutics. Furthermore, studies have reported enhanced antiviral activity when H-5 is used in combination with ribavirin, indicating the possibility of combination therapy for improved clinical efficacy.
Keywords Chikungunya Virus, Synthetic Bis-Naphthoquinone, H-5, Antiviral Activity, Viral Replication, Naphthoquinone Derivatives
Field Medical / Pharmacy
Published In Volume 8, Issue 4, July-August 2026
Published On 2026-08-12
DOI https://doi.org/10.36948/ijfmr.2026.v08i04.85628
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