Formulation and Invitro Evaluation of Ointment from Salicin & Curcumin for the Treatment of Varicose Veins

SUREGA M; MOHAMMED IRFAN S; MOHAMED ASIK AKTHAR R; BOOPATHY M; PONSAKTHI MEERA G S; ANANTHAJOTHI K; SANTHOSH S

Formulation and Invitro Evaluation of Ointment from Salicin & Curcumin for the Treatment of Varicose Veins

Author(s)	Mrs SUREGA M, Mr MOHAMMED IRFAN S, Mr MOHAMED ASIK AKTHAR R, Mr BOOPATHY M, Ms PONSAKTHI MEERA G S, Mrs ANANTHAJOTHI K, Mr SANTHOSH S
Country	India
Abstract	ABSTRACT Varicose veins are a common chronic venous disorder characterized by venous valve incompetence, venous hypertension, inflammation, pain, edema, and impaired blood circulation. The increasing interest in herbal medicine has encouraged the development of topical formulations containing bioactive phytochemicals with anti-inflammatory and antioxidant properties. The present study aimed to formulate and evaluate a herbal ointment containing salicin and curcumin for the treatment and management of varicose veins. Salicin was extracted from willow bark using aqueous and ethanolic extraction methods, while curcumin was extracted from turmeric rhizomes using acetone in a Soxhlet apparatus. The extracts were subjected to phytochemical screening and incorporated into an ointment base prepared by the fusion method. The formulated ointment was evaluated for physicochemical parameters including appearance, colour, Odor, pH, homogeneity, Spreadability, viscosity, extrudability, washability, stability, and skin irritation. In vitro anti-inflammatory activity was assessed by the protein denaturation inhibition assay. The formulation exhibited acceptable physicochemical characteristics with smooth consistency, good Spreadability, suitable pH, satisfactory viscosity, and excellent homogeneity. Stability studies indicated that the ointment remained stable without any evidence of phase separation or deterioration during the study period. The formulation also demonstrated significant concentration-dependent inhibition of protein denaturation, indicating promising anti-inflammatory activity. The synergistic effects of salicin and curcumin may contribute to reducing inflammation symptoms associated with varicose veins. The findings suggest that the developed herbal ointment is a promising topical formulation for the management of varicose veins. However, further preclinical and clinical studies are required to establish its therapeutic efficacy, safety, and long-term clinical benefits.
Keywords	Keywords: Varicose veins, Herbal ointment, Salicin, Curcumin, Anti-inflammatory activity, Protein denaturation assay, Soxhlet extraction, Topical drug delivery.
Field	Medical / Pharmacy
Published In	Volume 8, Issue 4, July-August 2026
Published On	2026-08-16

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Formulation and Invitro Evaluation of Ointment from Salicin & Curcumin for the Treatment of Varicose Veins

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