International Journal For Multidisciplinary Research
A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal
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Volume 5 Issue 6
Review on Vitamin D Tablet in Health and Disease Overview
|Author(s)||Harshwardhan Dhananjay Ghadge, Kalyanee Vijay Gavande, Amol Navnath Khedakar, Tanvir Santosh Rohokale|
|Abstract||This review aims to provide an overview of the current understanding regarding the relationship between muscle function and vitamin D. For many years, the molecular mechanisms of vitamin D's action on muscle tissue have been understood to involve both genomic and non-genomic effects. 1,25-dihydroxyvitamin D3 (1,25(OH)2D) binds to its nuclear receptor to start the genomic effects, which alter messenger RNA gene transcription and consequently protein synthesis. The membrane-bound vitamin D receptor (VDR) mediates the quick non-genomic effects of vitamin D. The significance of VDR polymorphisms in the development of osteoporosis and genetic variations in the VDR are still up for debate disagreement and discussion. VDR polymorphisms have most recently been reported to have an impact on muscle function. The body gets 80–100% of the vitamin D it needs from the skin, which has a huge capacity for producing the nutrient. The generation of vitamin D in the skin can be significantly impacted by age, latitude, time of day, and pigmentation. Elderly people in northern latitudes frequently have hypovitaminosis D. Elemental calcium is generally advised for people who are deficient in calcium and vitamin D since it lowers hip fractures and other non-vertebral fractures. Considering the close relationship between high parathyroid hormone levels, low serum calcium, and vitamin D deficiency.|
|Keywords||Muscle Function, Non-vertebral fractures, Vitamin D, Bone health, Osteoporosis.|
|Field||Medical / Pharmacy|
|Published In||Volume 5, Issue 6, November-December 2023|
|Cite This||Review on Vitamin D Tablet in Health and Disease Overview - Harshwardhan Dhananjay Ghadge, Kalyanee Vijay Gavande, Amol Navnath Khedakar, Tanvir Santosh Rohokale - IJFMR Volume 5, Issue 6, November-December 2023. DOI 10.36948/ijfmr.2023.v05i06.8734|
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