A Real-World Study on a Diabetes Prevention Programme for Bangladeshi Adults Aged 16-35

Hafiza Lona; Shahjada Selim; Md. Masud Rana

doi:10.36948/ijfmr.2026.v08i05.87473

A Real-World Study on a Diabetes Prevention Programme for Bangladeshi Adults Aged 16-35

Author(s)	Prof. Dr. Hafiza Lona, Dr. Shahjada Selim, Dr. Md. Masud Rana
Country	Bangladesh
Abstract	Background: Prevention of type 2 diabetes mellitus (T2DM) among high-risk individuals is a global public health priority. Lifestyle modification (LSM) and pharmacological interventions like metformin and pioglitazone have shown promising results in the prevention of T2DM. Objectives: This study was conducted to compare the effectiveness of lifestyle modification alone, lifestyle modification + metformin, and lifestyle modification + pioglitazone in preventing T2DM among high-risk individuals. Methods: This prospective interventional study was conducted from 2020 to 2023, among the 16-35 young Bangladeshi Adults. A total 1,405 participants were randomly assigned to lifestyle modification alone, lifestyle modification + metformin, and lifestyle modification + pioglitazone groups, respectively. The participants were similar in terms of baseline demographic and clinical characteristics (p > 0.05). Results: The incidence rate of diabetes was significantly higher in the LSM group than in the LSM+Met and LSM+Pio groups. The incidence rate per 100 person-years was 10.1, 6.4, and 5.0, respectively. The adjusted hazard ratio was 0.63 (95% CI, 0.52 to 0.76) for the LSM+Met group and 0.49 (95% CI, 0.40 to 0.60) for the LSM+Pio group. All groups showed a significant reduction in weight, BMI, and waist circumference. However, a greater reduction in weight was noted in the LSM+Met group than in the other groups. The reduction in weight was -5.2±2.1 kg, -3.5±1.5 kg, and -3.3±1.5 kg, respectively. A reduction in HbA1c and FBS was noted in all three groups. However, a greater reduction in HbA1c and FBS Conclusions: Both metformin and pioglitazone added significantly to the preventive effect of lifestyle modification against diabetes, and LSM+Pio had the lowest incidence of diabetes and the largest improvements in metabolism. However, safety profiles differ and should inform treatment choices.
Keywords	Diabetes prevention, Young adults, Lifestyle intervention, Metformin, Pioglitazone
Field	Medical / Pharmacy
Published In	Volume 8, Issue 5, September-October 2026
Published On	2026-09-12
DOI	https://doi.org/10.36948/ijfmr.2026.v08i05.87473

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A Real-World Study on a Diabetes Prevention Programme for Bangladeshi Adults Aged 16-35

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