International Journal For Multidisciplinary Research

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Volume 8 Issue 5
September-October 2026

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An Observational Study on Morning Dose V/s Evening Dose of Antihypertensive Drugs in Control of Blood Pressure and Outcomes

Author(s) Ms. Archana Vijai, Ms. Anitta K Mathew, Ms. Chanchal Richy Biju, Ms. Minnu James, Ms. Sandra Shine, DR. V L JAYAPRAKASH, DR. SANTHOSH MMATHEWS
Country India
Abstract Introduction: Hypertension is a chronic condition marked by persistently elevated arterial blood pressure, contributing significantly to global cardiovascular morbidity and mortality. While pharmacologic treatment is standard, the optimal timing of antihypertensive drug administration—morning versus evening—remains debated. This study aimed to compare the effectiveness of morning and evening dosing of antihypertensive medications in controlling blood pressure and influencing cardiovascular outcomes, medication adherence, and quality of life.
Methodology: A hospital based, single centred, observational study was conducted in the department of Cardiology, Pushpagiri Medical College Hospital, Thiruvalla, Kerala for a period of six months. The study was done in patients receiving antihypertensive therapy. A total of 300 study subjects were selected based on the inclusion and exclusion criteria.
Results: Baseline and post-treatment systolic and diastolic blood pressure showed no statistically significant differences between morning and evening groups. Adherence scores and SF-36 quality of life scores showed no significant variation between groups. The occurrence of cardiovascular outcomes, including myocardial infarction, stroke, and renal complications, was low and comparable between both groups (p>0.05).
Conclusion: The timing of antihypertensive drug administration, whether morning or evening, does not significantly affect blood pressure control, medication adherence, quality of life, or incidence of cardiovascular events. These findings support flexible dosing schedules based on patient convenience and clinical judgment.
Keywords Hypertension, Blood pressure control, Morning dose, Evening dose, Medication adherence, Quality of life.
Field Medical / Pharmacy
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-09-27
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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