International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 5
September-October 2026

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Delay in Recognition and Treatment of Sepsis in Emergency Departments: A Prospective Observational Study

Author(s) Ms. Harshini Ravi, Dr. Durgam Varsha, Dr. Sai Mouli Krishna Garre, Dr. Shreeya Singh, Ms. Renisha Kiruba S, Dr. Mohammed Khaja Moinudeen
Country India
Abstract Background: Sepsis remains a leading cause of morbidity and mortality globally, with outcomes heavily dependent on the promptness of recognition and antimicrobial administration in the emergency department (ED).
Objectives: To evaluate the frequency, causes, and clinical consequences of delays in the recognition and treatment of sepsis among adult emergency department patients.
Methods: A prospective observational study was conducted over a 12-month period across three tertiary care EDs, enrolling 1,248 adult patients presenting with sepsis or septic shock according to Sepsis-3 criteria. Data regarding triage vital signs, time to physician evaluation, time to lactate measurement, time to broad-spectrum antibiotic initiation, and in-hospital mortality were collected and analyzed using multivariable regression.
Results: The median time from ED arrival to physician evaluation was 42 minutes (IQR, 24–68), while the median time to intravenous antibiotic administration was 168 minutes (IQR, 112–235). Only 34.2% of patients received antibiotics within the benchmark 60-minute window. Each 60-minute delay in antibiotic administration was independently associated with a 1.18-fold increase in in-hospital mortality (adjusted odds ratio [aOR], 1.18; 95% confidence interval [CI], 1.09–1.28; p < 0.001) and prolonged intensive care unit (ICU) length of stay. Multivariable analysis identified triage by non-accredited nursing staff, atypical presentation (afebrile or normotensive), and ED overcrowding as primary independent predictors of treatment delay.
Conclusions: Significant delays in sepsis recognition and treatment persist in emergency departments, substantially worsening patient survival. Interventions must target early automated clinical decision support, rapid biomarker turnaround, and streamlined triage protocols.
Field Medical / Pharmacy
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-05
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E-ISSN 2582-2160
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CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

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