International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

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Volume 8 Issue 5
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Selected Micronutrients and Gut Health: Relationships with Gut Microbiota, Intestinal Barrier Function, and Immunity

Author(s) Ms. Lubna Bi Shaikh, Prof. Dr. Madhusudhan Nayak C
Country India
Abstract Deficiency of micronutrients has been linked to metabolic disorders like rickets, scurvy, and anemia for decades. But recent studies indicate that even deficiency of vitamins and minerals affects the function of the digestive tract and disrupts the immune system. Some important micronutrients like zinc, iron, and vitamins A, D, and B12 play a significant role in ensuring the balance between the host, gut bacteria, and the immune system. Deficiencies of these micronutrients can disrupt gut microbial composition, reduce SCFA-producing bacteria, and impair intestinal barrier function. Evidence from observational, experimental, and mechanistic studies suggests that micronutrient status is associated with differences in gut microbial composition, microbial metabolite production, intestinal barrier-associated processes, and immune regulation. However, the available evidence does not establish a single causal pathway from micronutrient deficiency to dysbiosis, barrier dysfunction, endotoxemia, and systemic immune dysregulation in humans. (Barone et al., 2022; Gombart et al., 2020; Guetterman et al., 2022)
This narrative review synthesizes evidence on the relationships between selected micronutrient deficiencies, gut microbial composition, intestinal barrier function, and immune regulation, with emphasis on the strength and limitations of evidence relevant to clinical nutrition.
Keywords Dysbiosis; Gut microbiota; Immune dysregulation; Intestinal permeability; Micronutrient deficiency.
Field Biology > Medical / Physiology
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-05
DOI https://doi.org/10.36948/ijfmr.2026.v08i05.89093
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