International Journal For Multidisciplinary Research

E-ISSN: 2582-2160   •   Impact Factor: 9.24

A Widely Indexed Open Access Peer Reviewed Multidisciplinary Bi-monthly Scholarly International Journal

Call for Paper Volume 8, Issue 5 (September-October 2026) Submit your research before last 3 days of October to publish your research paper in the issue of September-October.
Submit Research Paper Join as a Reviewer

Plagiarism is checked by the leading plagiarism checker TurnItIn

Call for Paper

Volume 8 Issue 5
September-October 2026

Submit your research paper

Indexing Partners
Academia Advanced Sciences Index Bielefeld Academic Search Engine CiteSeer DRJI Google Scholar Independent Search Engine & Directory Network ISI (International Scientific Indexing) Issuu Mendeley Research Networks
RefSeek ResearcherId - Thomson Reuters ResearchGate Scirus Scribd Semantic Scholar UTeM - Universiti Teknikal Malaysia Melaka Wiki for Call for Papers WorldCat Zenodo

Development of a Novel Garlic-Spirulina Bioactive Formulation for the Management of Dental Pain: A Translational Research Proposal

Author(s) Dr Sornamuki Arumugam, Aravinth Muthusamy
Country India
Abstract Dental pain is a common reason for patients to seek urgent dental care and is frequently associated with microbial infection, tissue injury, and inflammation. Although conventional analgesics remain the standard for pain control, naturally derived bioactive compounds may offer complementary antimicrobial, anti-inflammatory, and analgesic effects. Garlic (Allium sativum) contains organosulfur compounds, particularly allicin, with reported antimicrobial and anti-inflammatory properties against several oral pathogens. Spirulina platensis contains phycocyanin and bioactive peptides with antioxidant and inflammation-modulating potential, while clinical periodontal studies have reported encouraging effects on postoperative pain and analgesic consumption. This translational research proposes the development of a standardized garlic–Spirulina mucoadhesive oral formulation as a potential adjunct for dental pain management. The proposed investigation will proceed through formulation standardization, physicochemical and stability characterization, antimicrobial and antibiofilm testing, oral-cell cytotoxicity assessment, and mechanistic anti-inflammatory studies. Following demonstration of adequate preclinical safety, the formulation may be evaluated through a randomized controlled clinical study assessing pain intensity, rescue analgesic consumption, local inflammatory response, healing, and adverse effects. The proposed garlic–Spirulina combination is biologically plausible but remains investigational, and its efficacy and safety cannot be inferred from the individual ingredients alone. This research may establish a scientific foundation for a novel, locally acting bioactive adjunct for dental pain management.
Keywords Allium sativum, garlic, Spirulina platensis, phycocyanin, dental pain, analgesic, inflammation, phytotherapy, oral therapeutics.
Field Medical / Pharmacy
Published In Volume 8, Issue 5, September-October 2026
Published On 2026-10-10
DOI https://doi.org/10.36948/ijfmr.2026.v08i05.89332
View / Download PDF File

Share this



E-ISSN 2582-2160
CrossRef

CrossRef DOI prefix of IJFMR is 10.36948/ijfmr

Downloads
Research Paper Format Copyright Permission Form and Undertaking Form

All research papers published on this website are licensed under Creative Commons Attribution-ShareAlike 4.0 International License, and all rights belong to their respective authors/researchers.

CC-BY-SA Open Access

About IJFMR
Fees & Payment
Current Issue
Publication Archive 		Submit Research Paper
Track Submission Status
Publication Guidelines
Publication Ethics
Peer Review & Plagiarism 		Join as a Reviewer
Editors & Reviewers
Reviewer Referral Program
Get Reviewer Membership Certi. 		Website/Journal Policies
Usage Policy
Content Policies
Privacy Policy
Contact Us +91-9687-828-838 editor@ijfmr.com
Powered by Sky Research Publication and Journals